Oakland Raiders upset Indianapolis Colts, 38–31

The Raiders closed as 6.5-point underdogs and won outright.

It was the biggest of 4 NFL upsets in 2000 Week 2, and the 22nd-biggest of the 2000 season. It was Oakland Raiders's only upset win of 2000.

Other NFL upsets in 2000 Week 2

1. Cleveland Browns 24, Cincinnati Bengals 7

   6-point underdogRecap
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2. Detroit Lions 15, Washington Commanders 10

   5.5-point underdogRecap
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3. New Orleans Saints 28, San Diego Chargers 27

   5.5-point underdogRecap
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More: Oakland Raiders upsets · Indianapolis Colts upsets · all Week 2 upsets · how upset size works