St. Louis Rams beat Denver Broncos, 18–10

The Rams closed as 3.5-point underdogs and won outright.

It was the 3rd-biggest of 3 NFL upsets in 2006 Week 1, and the 55th-biggest of the 2006 season. St. Louis Rams pulled off 1 other upset in 2006.

Other NFL upsets in 2006 Week 1

1. Atlanta Falcons 20, Carolina Panthers 6

   4.5-point underdogRecap
   Upset size4.5
2. Minnesota Vikings 19, Washington Commanders 16

   4-point underdogRecap
   Upset size4

St. Louis Rams’ other 2006 upsets

1. St. Louis Rams 16, Arizona Cardinals 14

   Week 35.5-point underdogRecap
   Upset size5.5

More: St. Louis Rams upsets · Denver Broncos upsets · all Week 1 upsets · how upset size works