College football · NFLTuesday, October 13, 2026
The Upset Report
NFL · 2021 · Week 11 · Sunday, November 21, 2021

Indianapolis Colts upset Buffalo Bills, 41–15

The Colts closed as 7.5-point underdogs and won outright. The betting market gave them a 26% chance.

Final41–15
Upset size7.5
Chance to win26%
Rank in 202113th of 58

It was the 2nd-biggest of 3 NFL upsets in 2021 Week 11, and the 13th-biggest of the 2021 season. Indianapolis Colts pulled off 1 other upset in 2021.

Other NFL upsets in 2021 Week 11

  1. Houston Texans 22, Tennessee Titans 13
    10.5-point underdog20% to winRecap
    Upset size10.5
  2. Washington Commanders 27, Carolina Panthers 21
    3.5-point underdog38% to winRecap
    Upset size3.5

Indianapolis Colts’ other 2021 upsets

  1. Indianapolis Colts 30, San Francisco 49ers 18
    Week 73.5-point underdog39% to winRecap
    Upset size3.5

More: Indianapolis Colts upsets · Buffalo Bills upsets · all Week 11 upsets · how upset size works