Pittsburgh upsets No. 10 South Florida, 26–21
It was unranked Pittsburgh taking down the No. 10 team in the AP poll.
Final26–21
Upset size8
Rank in 20087th of 70
It was the biggest of 4 upsets in 2008 Week 6, and the 7th-biggest of the 2008 season. It was Pittsburgh's only upset win of 2008.
Other upsets in 2008 Week 6
No. 19 Vanderbilt 14, 
No. 13 Auburn 13Upset size3
Hawai'i 32, 
No. 22 Fresno State 29Upset size2
North Carolina 38, 
No. 24 UConn 12Upset size1
More: Pittsburgh upsets · South Florida upsets · all Week 6 upsets · the 2008 season · how upset size works