East Tennessee State stuns Vanderbilt, 23–3

East Tennessee State closed as a 21-point underdog and won outright.

It was the 3rd-biggest of 16 upsets in 2021 Week 1, and the 15th-biggest of the 2021 season. It was East Tennessee State's only upset win of 2021.

Other upsets in 2021 Week 1

1. Montana 13, No. 20 Washington 7

   22.5-point underdogUnranked beat No. 20FCS beat FBSRecap
   Upset size25.5
2. UC Davis 19, Tulsa 17

   22-point underdogFCS beat FBSRecap
   Upset size22
3. Northern Illinois 22, Georgia Tech 21

   19-point underdogRecap
   Upset size19
4. Utah State 26, Washington State 23

   17-point underdogRecap
   Upset size17
5. Virginia Tech 17, No. 10 North Carolina 10

   5.5-point underdogUnranked beat No. 10Recap
   Upset size13.5

More: East Tennessee State upsets · Vanderbilt upsets · all Week 1 upsets · the 2021 season · how upset size works