Louisville upsets No. 13 Southern Miss, 49–28
It was unranked Louisville taking down the No. 13 team in the AP poll.
Final49–28
Upset size6.5
Rank in 200020th of 56
It was the 2nd-biggest of 4 upsets in 2000 Week 11, and the 20th-biggest of the 2000 season. It was Louisville's only upset win of 2000.
Other upsets in 2000 Week 11
San José State 27, 
No. 9 TCU 24Upset size8.5- Upset size4.5
No. 3 Miami 41, 
No. 2 Virginia Tech 21Upset size0.5
More: Louisville upsets · Southern Miss upsets · all Week 11 upsets · the 2000 season · how upset size works