New England Patriots stun Indianapolis Colts, 38–17

The Patriots closed as 10.5-point underdogs and won outright.

All 2001 NFL Week 6 upsets, biggest first

An NFL upset is an underdog getting 3.5 or more points on the closing line winning outright. Upset size is the points it overcame. How it’s scored

1. New England Patriots 38, Indianapolis Colts 17

   10.5-point underdogRecap
   Upset size10.5
2. Buffalo Bills 13, Jacksonville Jaguars 10

   9-point underdogRecap
   Upset size9
3. Atlanta Falcons 20, New Orleans Saints 13

   8-point underdogRecap
   Upset size8
4. Cleveland Browns 24, Baltimore Ravens 14

   7.5-point underdogRecap
   Upset size7.5
5. Pittsburgh Steelers 17, Tampa Bay Buccaneers 10

   5-point underdogRecap
   Upset size5
6. Washington Commanders 17, Carolina Panthers 14

   3.5-point underdogOTRecap
   Upset size3.5