Clemson upsets No. 13 Wake Forest, 48–27
It was unranked Clemson taking down the No. 13 team in the AP poll.
Final48–27
Upset size6.5
Rank in 2021110th of 199
It was the 5th-biggest of 13 upsets in 2021 Week 12, and the 110th-biggest of the 2021 season. It was Clemson's only upset win of 2021.
Other upsets in 2021 Week 12
Southern Miss 35, 
Louisiana Tech 19Upset size15.5
No. 24 Utah 38, 
No. 4 Oregon 7Upset size10- Upset size9
South Carolina 21, 
Auburn 17Upset size7
Colorado 20, 
Washington 17Upset size6.5
More: Clemson upsets · Wake Forest upsets · all Week 12 upsets · the 2021 season · how upset size works