Holy Cross edges UConn, 38–28
Holy Cross closed as a 3-point underdog and won outright.
Final38–28
Upset size3
Rank in 2021182nd of 199
It was the 14th-biggest of 16 upsets in 2021 Week 1, and the 182nd-biggest of the 2021 season. It was Holy Cross's only upset win of 2021.
Other upsets in 2021 Week 1
Montana 13, 
No. 20 Washington 7Upset size25.5
UC Davis 19, 
Tulsa 17Upset size22
East Tennessee State 23, 
Vanderbilt 3Upset size21
Northern Illinois 22, 
Georgia Tech 21Upset size19
Utah State 26, 
Washington State 23Upset size17
More: Holy Cross upsets · UConn upsets · all Week 1 upsets · the 2021 season · how upset size works