San Francisco 49ers upset Los Angeles Rams, 26–23

The 49ers closed as 8.5-point underdogs and won outright in overtime. The betting market gave them a 22% chance.

All 2025 NFL Week 5 upsets, biggest first

An NFL upset is an underdog getting 3.5 or more points on the closing line winning outright. Upset size is the points it overcame. How it’s scored

1. San Francisco 49ers 26, Los Angeles Rams 23

   8.5-point underdog22% to winOTRecap
   Upset size8.5
2. Tennessee Titans 22, Arizona Cardinals 21

   7.5-point underdog22% to winRecap
   Upset size7.5
3. New England Patriots 23, Buffalo Bills 20

   7.5-point underdog23% to winRecap
   Upset size7.5
4. Denver Broncos 21, Philadelphia Eagles 17

   3.5-point underdog34% to winRecap
   Upset size3.5
5. Tampa Bay Buccaneers 38, Seattle Seahawks 35

   3.5-point underdog38% to winRecap
   Upset size3.5
6. Jacksonville Jaguars 31, Kansas City Chiefs 28

   3.5-point underdog36% to winRecap
   Upset size3.5